We explore the development, plasticity and functional specialization of dendritic cell subpopulations in antiviral immune defense and vaccine response. Investigating the response of dendritic cell subsets to viruses and their impact on T helper cell differentition is a focus of our work.
© J. Greune / LMU
Prof. Dr. Anne Krug
Institute for Immunology
Biomedical Center
LMU Munich
Großhadernerstr. 9
82152 Planegg-Martinsried
Germany
https://orcid.org/0000-0002-9556-7207207
Winheim E, Santos-Peral A, Ehm T, Rinke L, Riemer S, Zaucha M, Goresch S, Lehmann L, Eisenächer K, Pritsch M, Barba-Spaeth G, Straub T, Rothenfusser S, Krug AB. Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses. Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2422236122. doi: 10.1073/pnas.2422236122. Epub 2025 May 7. PMID: 40333758
Santos-Peral A, Zaucha M, Nikolova E, Yaman E, Puzek B, Winheim E, Goresch S, Scheck MK, Lehmann L, Dahlstroem F, Karimzadeh H, Thorn-Seshold J, Jia S, Luppa F, Pritsch M, Butt J, Metz-Zumaran C, Barba-Spaeth G, Endres S, Kim-Hellmuth S, Waterboer T, Krug AB, Rothenfusser S. Basal T cell activation predicts yellow fever vaccine response independently of cytomegalovirus infection and sex-related immune variations. Cell Rep Med. 2025 Feb 18;6(2):101946. doi: 10.1016/j.xcrm.2025.101946. Epub 2025 Feb 11. PMID: 39938525.
Antonio Santos-Peral, Fabian Luppa, Sebastian Goresch, Elena Nikolova, Magdalena Zaucha, Lisa Lehmann, Frank Dahlstroem, Hadi Karimzadeh, Julia Thorn-Seshold, Elena Winheim, Ev-Marie Schuster, Gerhard Dobler, Michael Hoelscher, Beate M. Kümmerer, Stefan Endres, Kilian Schober, Anne B. Krug, Michael Pritsch, Giovanna Barba-Spaeth & Simon Rothenfusser (2024 Feb 24) Prior flavivirus immunity skews the yellow fever vaccine response to cross-reactive antibodies with potential to enhance dengue virus infection. Nature Communications 15:1696. https://doi.org/10.1038/s41467-024-45806-x. PMID: 38402207
Manfred B Lutz, Shafaqat Ali, Cindy Audiger, Stella E Autenrieth, Luciana Berod, Venetia Bigley, Laura Cyran, Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez-Grau, Lucila Giusiano, Gloria J Godoy, Marion Heuer, Anne B Krug, Christian H K Lehmann, Christian T Mayer, Shalin H Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke (2023 Nov) Guidelines for mouse and human DC generation. Eur J Immunol 53(11):e2249816. doi: 10.1002/eji.202249816. Epub 2022 Oct 27. PMID: 36303448
Elena Winheim, Tabea Eser, Flora Deák, Mohamed I. M. Ahmed, Olga Baranov, Linus Rinke, Katharina Eisenächer, Antonio Santos-Peral, Hadi Karimzadeh, Michael Pritsch, Clemens Scherer, Maximilian Muenchhoff, Johannes C. Hellmuth, Michael von Bergwelt-Baildon, Laura Olbrich, Michael Hoelscher, Andreas Wieser, Inge Kroidl, Simon Rothenfusser, Christof Geldmacher, Anne B. Krug (2022 Nov 20) Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID-19 and after yellow fever vaccination. Eur J Immunology. doi: 10.1002/eji.202250090. PMID: 36404054
| Name | Title | Position | |
|---|---|---|---|
| Krug, Anne | Prof. Dr. med. | Group Leader | anne.krug@med.uni-muenchen.de |
| Dhavale, Apurva | MSc | Doctoral Researcher | apurva.dhavale@med.uni-muenchen.de |
| Reiner, Sandra | TA | Technische Assistentin | sandra.reiner@med.uni-muenchen.de |
| Riemer, Sandra | MSc | Doctoral Researcher | sandra.riemer@med.uni-muenchen.de |
| Schäfer, Yvonne | TA | Technische Assistentin | yvonne.schaefer@med-uni-muenchen.de |
| Shnipova, Margarita | MSc | Doctoral Researcher | margarita.shnipova@med.uni-muenchen.de |
| Starfas, Dimitrios | MSc | Doctoral Researcher | dimitrios.starfas@med.uni-muenchen.de |
| Vogt, Michael | MSc | Doctoral Researcher | Vogt.michael@med.uni-muenchen.de |